9.3.1.1 Advantages of Fully Differential Amplifiers
Input-coupling capacitors not required:
The fully differential amplifier allows the inputs to be biased at voltage other than mid-supply. The inputs of the TPA2080D1 can be biased anywhere within the common-mode input voltage range listed in Recommended Operating Conditions and Electrical Characteristics. If the inputs are biased outside of that range, input-coupling capacitors are required.
Midsupply bypass capacitor, C(BYPASS), not required:
The fully differential amplifier does not require a bypass capacitor. Any shift in the midsupply affects both positive and negative channels equally and cancels at the differential output.
Better RF-immunity:
GSM handsets save power by turning on and shutting off the RF transmitter at a rate of 217 Hz. The transmitted signal is picked up on input and output traces. The fully differential amplifier cancels the signal better than the typical audio amplifier.